The Cysteine-Inactivated Proteinase ( -antigen) of Clostridium histolyticum

Toxigenicity of Clostridium histolyticum.

Nishida, Shoki (Kanazawa University, Kanazawa, Japan), and Masaaki Imaizumi. Toxigenicity of Clostridium histolyticum. J. Bacteriol. 91:477-483. 1966.-From 234 soil samples, 21 strains of Clostridium histolyticum of different levels of alpha-toxigenicity were isolated by a new method specially designed for the isolation of this species. The alpha-toxigenicity of freshly isolated strains and of ...

i83. THE PROTEINASES OF CLOSTRIDIUM HISTOLYTICUM

Injectable collagenase clostridium histolyticum for Dupuytren's contracture.

BACKGROUND Dupuytren's disease limits hand function, diminishes the quality of life, and may ultimately disable the hand. Surgery followed by hand therapy is standard treatment, but it is associated with serious potential complications. Injection of collagenase clostridium histolyticum, an office-based, nonsurgical option, may reduce joint contractures caused by Dupuytren's disease. METHODS W...

Ccxx. Enzymic Adaptation in Clostridium Histolyticum

RECENTLY Kocholaty & Hoogerheide [1938] described an example of the adaptation of certain of the endo-enzymes of the strict anaerobe Cl. sporogenes: by varying thepH ofthe culture medium a considerable shift in the pH optimum of some of the dehydrogenases could be produced. It has now been found that under specified conditions the pH optimum of the proteinase secreted by this micro-organism can...

The Partial Purification of the Lethal Toxin of Clostridium Histolyticum *

Although several bacterial toxins have been prepared in highly purified form (c.f. Pappenheimer,6 Lamanna et al,,' and Pillemer8), comparatively little effort has been made in this direction with the toxins of the gas gangrene organism C. histolyticurm. Weinberg and Seguinll demonstrated that it could be precipitated with ammonium sulfate, and made the observation that ethanol destroys the toxi...